孙振璐;宫连凤;韩文清;刘娟;徐小雯;刘军;王志昱;高巧;张彩骥;

• 1:烟台市疾病预防控制中心
• 2:烟台市毓璜顶医院

摘要(Abstract)：

目的对烟台市2010~2015年手足口病(hand-foot-mouth disease,HFMD)病例进行核酸检测及病原学分析。方法在2010~2015年烟台各县市区临床诊断的HFMD病例(包括门诊轻症病例和住院重症病例)中,每月采集5例首次就诊的普通病例及所有重症和死亡病例的咽拭子标本,RT-PCR法进行肠道病毒(enterovirus,EV)核酸检测。结果 2010~2015年烟台市HFMD病例年均报告发病率68.68/10万,重症病例占0.36%,男女性别比例为1.81∶1,发病以低于5岁幼儿为主,占91.22%,每年5~8月为发病高峰。病原谱构成差异有统计学意义(P<0.01),其中EV71型769例,占30.95%,柯萨奇病毒A16型(coxsackievirus A16,Cox A16)814例,占32.76%,其他EV型902例,占36.30%。HFMD病原体以EV71和Cox A16交替为主,其中重症患者的主要致病原为EV71(52.54%)。结论烟台市2010~2015年EV71、Cox A16和其他EV交替为HFMD病例的主要病原体,HFMD的发病存在明显季节、性别、年龄差异,重症病例的主要致病原为EV71,应加强对该型别的监测,防控工作重点为托幼机构及小学低年级儿童。

关键词(KeyWords)： 手足口病;肠道病毒;核酸检测;病原学分析

Abstract:

Keywords:

基金项目(Foundation): 烟台市科技发展计划项目(2012114)

作者(Author): 孙振璐;宫连凤;韩文清;刘娟;徐小雯;刘军;王志昱;高巧;张彩骥;

Email:

DOI: 10.13200/j.cnki.cjb.001660

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