何淑云;王轶文;乔建国;付博;范学彬;姜崴;
HE Shu-yun;WANG Yi-wen;QIAO Jian-guo;FU Bo;FAN Xue-bin;JIANG Wei;Center for Disease Prevention and Control of Jilin City;

• 1:吉林市疾病预防控制中心
• 2:长春生物制品研究所有限责任公司

摘要(Abstract)：

目的评价森林脑炎灭活疫苗加强免疫后的免疫效果。方法选择吉林市森林脑炎发病率较高的蛟河市、舒兰市既往有森林脑炎疫苗基础免疫史的400名8岁及以上健康人群,于基础免疫后18个月,进行1剂加强免疫,加强免疫1个月后,采集受试者静脉血,分离血清,使用森林脑炎Ig G ELISA试剂盒测定血清Ig G抗体水平。结果 400名受试者中,失访61人,共339人完成加强免疫,男女比例为3.35∶1;抗体阳性325人,阳性率为95.87%,GMC为3 391 VIEU/ml,其中8¹6岁、1716岁、17⁵9岁及60岁以上年龄组抗体阳性率差异无统计学意义(P>0.05),但GMC差异有统计学意义(P<0.01),男、女抗体阳性率及GMC差异均有统计学意义(P<0.05)。结论受试者加强免疫后抗体阳性率较高,产生了高滴度的保护性抗体。
Objective To evaluate the booster immune effect of inactivated tick-borne encephalitis vaccine. Methods Healthy persons living in Jiaohe and Shulan County-level cities, Jilin City, Jilin Province, China with relatively high incidence of tick-borne encephalitis, at ages of not less than 8 years, were boosted with a single dose of inactivated tick-borne vaccine 18 months after basic immunization, of whom serum samples were collected and determined for Ig G level by ELISA kit. Results Of the 400 subjects, 61 were lost to follow up. Of the 339 subjects receiving booster immunization,the ratio of male to female ones was 3. 35 ∶ 1, while 325 were positive for Ig G, indicating a positive rate of 95. 87%, and the GMC of Ig G was 3 391 VIEU / ml. The antibody positive rates of subjects at ages of 8 59岁及60岁以上年龄组抗体阳性率差异无统计学意义(P>0.05),但GMC差异有统计学意义(P<0.01),男、女抗体阳性率及GMC差异均有统计学意义(P<0.05)。结论受试者加强免疫后抗体阳性率较高,产生了高滴度的保护性抗体。
Objective To evaluate the booster immune effect of inactivated tick-borne encephalitis vaccine. Methods Healthy persons living in Jiaohe and Shulan County-level cities, Jilin City, Jilin Province, China with relatively high incidence of tick-borne encephalitis, at ages of not less than 8 years, were boosted with a single dose of inactivated tick-borne vaccine 18 months after basic immunization, of whom serum samples were collected and determined for Ig G level by ELISA kit. Results Of the 400 subjects, 61 were lost to follow up. Of the 339 subjects receiving booster immunization,the ratio of male to female ones was 3. 35 ∶ 1, while 325 were positive for Ig G, indicating a positive rate of 95. 87%, and the GMC of Ig G was 3 391 VIEU / ml. The antibody positive rates of subjects at ages of 8 16, 17 16, 17 59 and more than 60 years showed no significant difference(P > 0. 05), while the GMCs showed significant difference(P < 0. 01). However,both the positive rates and GMCs of Ig G in male and female subjects showed significant difference(P < 0. 05). Conclusion High positive rate and titer of protective antibody were induced by booster immunization with inactivated tick-borne encephalitis vaccine.

关键词(KeyWords)： 森林脑炎灭活疫苗;加强免疫
Inactivated tick-borne encephalitis vaccine;Booster immunization

Abstract:

Keywords:

基金项目(Foundation): 吉林省科技发展计划项目(20130102071JC)

作者(Authors): 何淑云;王轶文;乔建国;付博;范学彬;姜崴;
HE Shu-yun;WANG Yi-wen;QIAO Jian-guo;FU Bo;FAN Xue-bin;JIANG Wei;Center for Disease Prevention and Control of Jilin City;

DOI: 10.13200/j.cnki.cjb.000851

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