冻干保护剂在活疫苗生产中的应用进展Progress of application of lyophilization stabilizer in live vaccine production
李键;
摘要(Abstract):
冻干是疫苗研发及制备过程中的关键技术,在疫苗冻干及储藏过程中疫苗的化学成分、冻结温度和速率、干燥温度及干燥固体中剩余水分、储藏环境的温度和湿度等均会对疫苗的活性产生影响。为防止疫苗在冻干过程中活性组分的变性,需添加合适的冻干保护剂,可尽量减少冻干及储藏过程对疫苗活性造成的损伤。本文就几种常见冻干保护剂的保护机理及应用、筛选方法与面临的挑战及其未来的发展趋势作一综述。
关键词(KeyWords): 冻干保护剂;活疫苗;病毒滴度
基金项目(Foundation):
作者(Authors): 李键;
DOI: 10.13200/j.cnki.cjb.001671
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