李键;

• 1:上海交通大学生命科学技术学院

摘要(Abstract)：

冻干是疫苗研发及制备过程中的关键技术,在疫苗冻干及储藏过程中疫苗的化学成分、冻结温度和速率、干燥温度及干燥固体中剩余水分、储藏环境的温度和湿度等均会对疫苗的活性产生影响。为防止疫苗在冻干过程中活性组分的变性,需添加合适的冻干保护剂,可尽量减少冻干及储藏过程对疫苗活性造成的损伤。本文就几种常见冻干保护剂的保护机理及应用、筛选方法与面临的挑战及其未来的发展趋势作一综述。

关键词(KeyWords)： 冻干保护剂;活疫苗;病毒滴度

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李键;

Email:

DOI: 10.13200/j.cnki.cjb.001671

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