经S/D灭活病毒后新型凝血酶原复合物性质的研究Study on Characteristics of A Newtype Prothrombin Complex Concentrate After the Virus Inactivation by S/D Method
余蓉,袁野,肖小璞,赵青蓉,曾洁,闻欣,张鹏飞,许素清
摘要(Abstract)：
对经有机溶剂／表面活性剂（S／D）处理后的新型凝血酶原复合物（PCC）与未经S／D处理的传统PCC进行对比分析，结果显示新型PCC不仅充分地保留了有效成分，且F-Ⅸ：C的比活性提高显著（P＜0．01）。经SDS－PAGE、IE、CIE电泳及HPLC分析均反映出新型PCC的纯度有所改善，NAPTT和TGt50实验结果显示新型PCC明显优于传统PCC（P＜0．05及P＜0．01）；采用兔Stasis模型进行Wessler试验，新型PCC的体内最小致血栓剂量＞43PE／kg，其ED50至少高于传统PCC2倍以上。
关键词(KeyWords)： 凝血酶原复合物;S／D处理;性质
基金项目(Foundation): 中国医学科学院科研基金
作者(Author): 余蓉,袁野,肖小璞,赵青蓉,曾洁,闻欣,张鹏飞,许素清
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DOI: 10.13200/j.cjb.1997.03.148.yur.007
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